ognizant Communication Corporation





Copper Chelation as an Antiangiogenic Therapy
S. A. Lowndes and A. L. Harris

Laboratory Research

Design and Construction of a Phosphorylatable Chimeric Monoclonal Antibody With a Highly Stable Phosphate
Wei Wu, John E. Kerrigan, Prem Yadav, Barbara Schwartz, Lara Izotova, Thomas B. Lavoie, and Sidney Pestka

Radiation-Induced Sensitizing Effect of Folic Acid (Vitamin B11) and its Synergistic Action to Mitomycin C: In Vitro Experiments and Radiolysis
Alexandra Delipetar-Grudl and Nikola Getoff

Resistance of Ovarian Carcinoma Cells to Docetaxel Is XIAP Dependent and Reversible by Phenoxodiol
Eva Sapi, Ayesha B. Alvero, Wei Chen, David O'Malley, Xiao-Ying Hao, Bambang Dwipoyono, Manish Garg, Marijke Kamsteeg, Thomas Rutherford, and Gil Mor

The Unique Biological Features of the Marine Product YondelisTM (ET-743, Trabectedin) Are Shared by its Analog ET-637, Which Lacks the C Ring
E. Erba, E. Cavallaro, G. Damia, R. Mantovani, A. Di Silvio, A. M. Di Francesco, R. Riccardi, C. Cuevas, G. T. Faircloth, and M. D'Incalci

secErbB4-26/549 Antagonizes Ligand-Induced ErbB4 Tyrosine Phosphorylation
Jennifer L. Gilmore and David J. Riese, II

Clinical Research

Serum Levels of Soluble E-Selectin Are Associated With the Clinical Course of Metastatic Disease in Patients With Liver Metastases From Breast Cancer
Michael H. R. Eichbaum, Thomas M. de Rossi, Sepp Kaul, and Gunther Bastert

Concentrations of VEGF and VEGFR1 in Paired Tumor Arteries and Veins in Patients With Rectal Cancer
Mads N. Svendsen, Jakob Lykke, Kim Werther, Ib J. Christensen, and Hans J. Nielsen

Volume 14 Subject and Author Index


Laboratory Research

The Ability of New Sugar-Modified Derivatives of Antitumor Anthracycline, Daunorubicin, to Stimulate NAD(P)H Oxidation in Different Cellular Oxidoreductase Systems: NADH Dehydrogenase, NADPH Cytochrome P450 Reductase, and Xanthine Oxidase
Jolanta Pawlowska, Waldemar Priebe, Mark J. I. Paine, C. Roland Wolf, Edward Borowski, and Jolanta Tarasiuk

PAR1-Type Thrombin Receptor Stimulates Migration and Matrix Adhesion of Human Colon Carcinoma Cells by a PKCe-Dependent Mechanism
Ilonka Heider, Beate Schulze, Elke Oswald, Peter Henklein, Johannes Scheele, and Roland Kaufmann

Nicotinamide Relaxes Vascular Smooth Muscle by Inhibiting Myosin Light Chain Kinase-Dependent Signaling Pathways: Implications for Anticancer Efficacy
Mark W. Ruddock and David G. Hirst

The Differential Proteome Profile of Stomach Cancer: Identification of the Biomarker Candidates
Joung S. Jang, Hee Y. Cho, Young J. Lee, Woo S. Ha, and Hwal W. Kim

Proteolysis of Human Plasma Reveals the Presence of Complexes Formed by Endogenous Heparin and Peptides That Stimulate Angiogenesis
Stefania Pacini, Marco Ruggiero, Fabiola Cecchi, Benedetta Peruzzi, and Simonetta Vannucchi

In Vivo Molecular Pharmacology and Antitumor Activity of the Targeted Akt Inhibitor PX-316
Emmanuelle J. Meuillet, Nathan Ihle, Amanda F. Baker, Jaime M. Gard, Chelsea Stamper, Ryan Williams, Amy Coon, Daruka Mahadevan, Benjamin L. George, Lynn Kirkpatrick, and Garth Powis


Laboratory Research

4-[3,5-bis(trimethylsilyl)benzamido] Benzoic Acid Inhibits Angiogenesis in Colon Cancer Through Reduced Expression of Vascular Endothelial Growth Factor
Noritaka Minagawa, Yoshifumi Nakayama, Yuzuru Inoue, Koji Onitsuka, Takefumi Katsuki, Yosuke Tsurudome, Kazunori Shibao, Keiji Hirata, Tatsuhiko Sako, Naoki Nagata, Shinji Ohie, Kimitoshi Kohno, and Hideaki Itoh

Resveratrol and Propolis as Necrosis or Apoptosis Inducers in Human Prostate Carcinoma Cells
Christian Scifo, Venera Cardile, Alessandra Russo, Rosanna Consoli, Carlo Vancheri, Francesco Capasso, Angelo Vanella, and Marcella Renis

Modulation of Wnt-Specific Colon Cancer Cell Kill by Butyrate and Lithium
Michael Bordonaro, Darina L. Lazarova, Rocco Carbone, and Alan C. Sartorelli

Cell-Free DNA and RNA in Plasma as a New Molecular Marker for Prostate Cancer
Eirini Papadopoulou, Elias Davilas, Vasilios Sotiriou, Alexander Koliopanos, Filipos Aggelakis, Konstantinos Dardoufas, Niki J. Agnanti, Irini Karydas, and Georgios Nasioulas

Radiosensitization of Colon Cancer Cell Lines by Docetaxel: Mechanisms of Action
Amanda L. Dunne, Carmel Mothersill, Tracy Robson, George D. Wilson, and David G. Hirst

PEG Prodrugs of 6-Mercaptopurine for Parenteral Administration Using Benzyl Elimination of Thiols
Yun H. Choe, Richard B. Greenwald, Charles D. Conover, Hong Zhao, Clifford B. Longley, Shuiyun Guan, Qiuxia Zhao, and Jing Xia


Brief Communication

Diagnostic, Endocrinological, Behavioral, and DNA Ploidy Differences Between Squamous Cell and Adenomatous Carcinoma of the Cervix Uteri
Annika Kristina Lindström, Dan Hellberg, Torbjörn Bäckström, and Ulf Stendahl

Effect of Association of Temozolomide With Other Chemotherapic Agents on Cell Growth Inhibition in Glioma Cell Lines
Marco Balzarotti, Emilio Ciusani, Chiara Calatozzolo, Danilo Croci, Amerigo Boiardi, and Andrea Salmaggi

Laboratory Research

Age-Related Differences in Vincristine Toxicity and Biodistribution in Wild-Type and Transporter-Deficient Mice
Toshinari Muramatsu, Dennis R. Johnson, Rick A. Finch, Linda K. Johnson, Janine J. Leffert, Z. Ping Lin, Giuseppe Pizzorno, and Alan C. Sartorelli

The Cellular Response to PPARg Ligands Is Related to the Phenotype of Neuroblastoma Cell Lines
Tiziana Servidei, Roberta Morosetti, Cristiano Ferlini, Gabriella Cusano, Giovanni Scambia, Renato Mastrangelo, and H. Phillip Koeffler

Screening Novel, Potent Multidrug-Resistant Modulators From Imidazole Derivatives
Li-ming Chen, Xing-Ping Wu, Ji-wu Ruan, Yong-ju Liang, Yan Ding, Zhi Shi, Xiu-wen Wang, Lian-Quan Gu, and Li-wu Fu

Apoptosis of Human T-Cell Acute Lymphoblastic Leukemia Cells by Diphenhydramine, an H1 Histamine Receptor Antagonist
Shawkat-Muhialdin Jangi, Aintzane Asumendi, Jon Arlucea, Naiara Nieto, Gorka Perez-Yarza, María C. Morales, María de la Fuente-Pinedo, and María D. Boyano

Status of Methylthioadenosine Phosphorylase and its Impact on Cellular Response to L-Alanosine and Methylmercaptopurine Riboside in Human Soft Tissue Sarcoma Cells
WeiWei Li, Dan Su, Hiroo Mizobuchi, Daniel S. Martin, Bin Gu, Richard Gorlick, Peter Cole, and Joseph R. Bertino

Differential Effects of Doxorubicin and Docetaxel on Nitric Oxide Production and Inducible Nitric Oxide Synthase Expression in MCF-7 Human Breast Cancer Cells
Gulperi Oktem, Bulent Karabulut, Nur Selvi, Canfeza Sezgin, Ulus Ali Sanli, Ruchan Uslu, Mine Ertem Yurtseven, and Serdar Bedii Omay

Inhibitory Effect of Topical Applications of Nondenatured Soymilk on the Formation and Growth of UVB-Induced Skin Tumors
Mou-Tuan Huang, Jian-Guo Xie, Connie B. Lin, Menas Kizoulis, Miri Seiberg, Stanley Shapiro, and Allan H. Conney

Evidence That General Genomic Hypomethylation and Focal Hypermethylation Are Two Independent MolecularEevents of Non-Hodgkin's Lymphoma
Janelle T. Pini, Maria Franchina, Jeremy M. E. Taylor, and Peter H. Kay



Structural Insights Into AGC Kinase Inhibition
Christine Breitenlechner, Michael Gaßel, Richard Engh, and Dirk Bossemeyer

Laboratory Research

Formation of Mitoxantrone Adducts in Human Tumor Cells: Potentiation by AN-9 and DNA Methylation
Belinda S. Parker, Ada Rephaeli, Abraham Nudelman, Don R. Phillips, and Suzanne M. Cutts

Minimal Residual Disease in Neuroblastoma: To GAGE or not to GAGE
S. Oltra, F. Martínez, C. Orellana, E. Grau, J. M. Fernández, A. Cañete, and V. Castel

Estimation of Radiation-Induced Interphase Cell Death in Cultures of Human Tumor Material and in Cell Lines
Elaine S. Marshall, Bruce C. Baguley, John H. L. Matthews, Chakiath C. Jose, Christopher E. Furneaux, James H. F. Shaw, James A. Kirker, Randall P. Morton, Julian B. White, Michael L. Rice, Richard J. Isaacs, Richard Coutts, and John R. Whittaker

A Scalable High-Content Cytotoxicity Assay Insensitive to Changes in Mitochondrial Metabolic Activity
Andreas Vogt, Erica N. Kalb, and John S. Lazo

Clinical Research

Metabolic Polymoryphisms, Smoking, and Oral Cancer in Puerto Rico
Heng Xie, Lifang Hou, Peter G. Shields, Deborah M. Winn, Gloria Gridley, Eleuterio Bravo-Otero, Scott R. Diehl, Elise D. Bowman, Linda M. Brown, and Richard B. Hayes



Emerging Roles of Targeted Small Molecule Protein-Tyrosine Kinase Inhibitors in Cancer Therapy
John K. Smith, Naila M. Mamoon, and Roy J. Duhé

Inhibition of Angiogenesis by Salmosin Expressed In Vitro
Soo In Kim, Keun Sik Kim, Hong Sung Kim, Myoung Min Choi, Doo Sik Kim, Kwang Hoe Chung, and Yong Serk Park

Hydroxyurea-Induced Apoptosis in an EBV-Immortalized Lymphoblastoid Cell Line
Pauline Huyghe, Laurent Dassonneville, Pierre Fenaux, and Christian Bailly

Synthesis and In Vitro Cytotoxicity Studies of Novel L-Tryptophan-Polyamide Conjugates and L-Tryptophan Dimers Linked With Aliphatic Chains and Polyamides
Rohtash Kumar, Dinesh Rai, and J. William Lown


Structure-Activity Relationship for Alkylating Dipeptide Nitrogen Mustard Derivatives
Joachim Gullbo, Marcus Tullberg, Jon Våbenø, Hans Ehrsson, Rolf Lewensohn, Peter Nygren, Rolf Larsson, and Kristina Luthman

Shifting Gene Expression Profiles During Ex Vivo Culture of Renal Tumor Cells: Implications for Cancer Immunotherapy
Federica Moschella, Richard P. Catanzaro, Brygida Bisikirska, Ihor S. Sawczuk, Kyriakos P. Papadapoulos, Anthony W. Ferrante, Jr., James M. McKiernan, Charles S. Hesdorffer, Paul E. Harris, and Antonella Maffei

In Vitro Antitumor Structure-Activity Relationships of threo/trans/threo mono-Tetrahydrofuranic Acetogenins: Correlations With Their Inhibition of Mitochondrial Complex I
José R. Tormo, Inmaculada Royo, Teresa Gallardo, M. Carmen Zafra-Polo, Pilar Hernández, Diego Cortes, and Fernando Peláez

Pleural Mesothelial Cell (PMC) Defense Mechanisms Against Malignancy
Najmunnisa Nasreen, Kamal A. Mohammed, Kerry Sanders, Joyce Hardwick, Robert D. Van Horn, P. S. Sriram, Carlos Ramirez-Icaza, Chadi Hage, and Veena B. Antony

Expression of c-Met Proto-oncogene in Metastatic Macrophage x Melanoma Fusion Hybrids: Implication of Its Possible Role in MSH-Induced Motility
Ashok K. Chakraborty, Natalia Kolesnikova, Josane de Freitas Sousa, Enilza Maria Espreafico, Kamila Chagas Peronni, and John Pawelek


Frequent Alterations of Smad Signaling in Human Head and Neck Squamous Cell Carcinomas: A Tissue Microarray Analysis
Wen Xie, Savita Bharathy, David Kim, Bruce G. Haffty, David L. Rimm, and Michael Reiss

Effect of 3-Fluorothalidomide and 3-Methylthalidomide Enantiomers on Tumor Necrosis Factor Production and Antitumor Responses to the Antivascular Agent 5,6-Dimethylxanthenone-4-Acetic Acid (DMXAA)
Francisco Chung, Brian D. Palmer, George W. Muller, Hon-Wah Man, Phillip Kestell, Bruce C. Baguley, and Lai-Ming Ching

Epidermal Growth Factor-Responsive Laryngeal Squamous Cancer Cell Line Hep2 Is More Sensitive Than Unresponsive CO-K3 One to Quercetin and Tamoxifen Apoptotic Effects
G. Raspaglio, G. Ferrandina, C. Ferlini, G. Scambia, and F. O. Ranelletti

Reduction of Bladder Cancer Cell Growth in Response to hCGb CTP37 Vaccinated Mouse Serum
Stephen A. Butler, Edyta M. Staite, and Ray K. Iles

Characterization of Prostate Cancer DU145 Cells Expressing the Recombinant Androgen Receptor
Eugenia Scaccianoce, Claudio Festuccia, Donatella Dondi, Vittoria Guerini, Mauro Bologna, Marcella Motta, and Angelo Poletti


Modeling the Interaction of Paclitaxel With b-Tubulin
Michael T. G. Ivery and Tuyet Le

Reductive Metabolism of the Nitroimidazole-Based Hypoxia-Selective Cytotoxin NLCQ-1 (NSC 709257)
Maria V. Papadopoulou, Ming Ji, Mira K. Rao, and William D. Bloomer

Increased Activity and Expression of Phospholipase D2 in Human Colorectal Cancer
Hirokazu Oshimoto, Shinichi Okamura, Makoto Yoshida, and Masatomo Mori

Binding Site(s) on P-Glycoprotein for a Newly Synthesized Photoaffinity Analog of Agosterol A
Masahiko Mitsuo, Tomohiro Noguchi, Yuichi Nakajima, Shunji Aoki, Xiao-Qin Ren, Tomoyuki Sumizawa, Misako Haraguchi, Motomasa Kobayashi, Masanori Baba, Yukihiro Nagata, Shin-ichi Akiyama, and Tatsuhiko Furukawa

Development of a Syngeneic In Vivo Tumor Model and its Use in Evaluating a Novel P-Glycoprotein Modulator, PGP-4008
Brian D. Lee, Kevin J. French, Yan Zhuang, and Charles D. Smith