Cell Medicine : An online free-to-read journal. See full text articles below.

Editor: Dr. Dragos Cretoiu

ISSN: 2155-1790

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Cell Medicine publishes original, open access, peer-reviewed research and review articles on the subject of cell therapy and its translational application to human diseases. For full Aims & Scope, please visit:

https://us.sagepub.com/en-us/nam/cell-medicine/journal203417#aims-and-scope

 

 

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Volume 9, Number 3

Commentary

Regenerative Rehabilitation: An Innovative and Multifactorial Approach to Recovery From Stroke and Brain Injury 67
Samantha M. Portis and Paul R. Sanberg

Original Contributions

Neurovascular Cell Sheet Transplantation in a Canine Model of Intracranial Hemorrhage 73
Woo-Jin Lee, Jong Young Lee, Keun-Hwa Jung, Soon-Tae Lee, Hyo Yeol Kim, Dong-Kyu Park, Jung-Suk Yu, So-Yun Kim, Daejong Jeon, Manho Kim, Sang Kun Lee, Jae-Kyu Roh, and Kon Chu

A Prospective, Nonrandomized, no Placebo-Controlled, Phase I/II Clinical Trial Assessing the Safety and Efficacy of Intramuscular Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells in Patients With Severe Buerger’s Disease 87
Jeong Chan Ra, Euicheol C. Jeong, Sung Keun Kang, Seog Ju Lee, and Kyoung Ho Choi

Human Adipose-Derived Mesenchymal Stem Cells Respond to Short-Term Hypoxia by Secreting Factors Beneficial for Human Islets In Vitro and Potentiate Antidiabetic Effect In Vivo 103
Simen W. Schive, Mohammad Reza Mirlashari, Grete Hasvold, Mengyu Wang, Dag Josefsen, Hans Petter Gullestad, Olle Korsgren, Aksel Foss, Gunnar Kvalheim, and Hanne Scholz

Higher Serum Alanine Transaminase Levels in Male Urokinase-Type Plasminogen Activator-Transgenic Mice Are Associated With Improved Engraftment of Hepatocytes but not Liver Sinusoidal Endothelial Cells 117
Marina E. Fomin, Ashley I. Beyer, Jean Publicover, Kai Lu, Sonia Bakkour, Graham Simmons, and Marcus O. Muench

Volume 9, Numbers 1-2
JSOPMB Issue

Facilitating Transplantation 1
Hirofumi Noguchi

Cell Therapy for Liver Disease Using Bioimaging Rats 3
Junko Haga, Shin Enosawa, and Eiji Kobayashi

Challenges for Production of Human Transplantable Organ Grafts 9
Eiji Kobayashi

Evaluation of Serum-Free, Xeno-Free Cryopreservation Solutions for Human Adipose-Derived Mesenchymal Stem Cells 15
Chika Miyagi-ShiohiraNaoya Kobayashi, Issei Saitoh, Masami Watanabe, Yasufumi Noguchi, Masayuki Matsushita, and Hirofumi Noguchi

Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells on Concanavalin A-Induced Acute Liver Injury in Mice 21
Yasuma Yoshizumi, Hiroshi Yukawa, Ryoji Iwaki, Sanae FujinakaAyano Kanou, Yuki Kanou, Tatsuya Yamada, Shingo Nakagawa, Tomomi Ohara, Kenta Nakagiri, Yusuke Ogihara, Yoko TsutsuiYumi Hayashi, Masatoshi IshigamiYoshinobu Baba, and Tetsuya Ishikawa

Enhanced Adipogenic Differentiation of Human Adipose-Derived Stem Cells in an In Vitro Microenvironment: The Preparation of Adipose-Like Microtissues Using a Three-Dimensional Culture 35
Yoshitaka Miyamoto, Masashi Ikeuchi, Hirofumi Noguchi, Tohru Yagi, and Shuji Hayashi

The Evaluation of Islet Purification Methods That Use Large Bottles to Create a Continuous Density Gradient 45
Chika Miyagi-ShiohiraNaoya Kobayashi, Issei Saitoh, Masami Watanabe, Yasufumi Noguchi, Masayuki Matsushita, and Hirofumi Noguchi

Comparison of Purification Solutions With Different Osmolality for Porcine Islet Purification 53
Chika Miyagi-ShiohiraNaoya Kobayashi, Issei Saitoh, Masami Watanabe, Yasufumi Noguchi, Masayuki Matsushita, and Hirofumi Noguchi

Measurement of DNA Length Changes Upon CpG Hypermethylation by Microfluidic Molecular Stretching 61
Daisuke Onoshima, Naoko Kawakita, Daiki Takeshita, Hirohiko Niioka, Hiroshi Yukawa, Jun Miyake, and Yoshinobu Baba

Volume 8, Number 3

Allogeneic Mesenchymal Stem Cell Transplantation in Dogs With Keratoconjunctivitis Sicca 63
Maura K. W. Bittencourt, Michele A. Barros, João Flávio P. Martins, Jose Paulo C. Vasconcellos, Bruna P. Morais, Celine Pompeia, Matheus Domingues BittencourtKarine dos Santos Evangelho, Irina Kerkis, and Cristiane V. Wenceslau

αSMA Expression in Large Colonies of Colony-Forming Units-Fibroblast as an Early Predictor of Bone Marrow MSC Expandability 79
Irina Aizman, William S. Holland, Cher Yang, and Damien Bates

Stability Enhancement Using Hyaluronic Acid Gels for Delivery of Human Fetal Progenitor Tenocytes 87
A. Grognuz, C. Scaletta, A. Farron, D. P. Pioletti, W. Raffoul, and L. A. Applegate

Aggregation of Engineered Human β-Cells Into Pseudoislets: Insulin Secretion and Gene Expression Profile in Normoxic and Hypoxic Milieu 99
Marie-José LecomteSéverine Pechberty, Cécile Machado, Sandra Da Barroca, Philippe Ravassard, Raphaël Scharfmann, Paul Czernichow, and Bertrand Duvillié

Volume 8, Numbers 1–2
JSOPMB Issue

Creating a Future of Transplantation 1
Hirofumi Noguchi, Guest Editor-in-Chief, JSOPMB Issue

Review
Cryopreservation of Adipose-Derived Mesenchymal Stem Cells 3
Chika Miyagi-Shiohira, Kiyoto KurimaNaoya Kobayashi, Issei Saitoh, Masami Watanabe, Yasufumi Noguchi, Masayuki Matsushita, and Hirofumi Noguchi

Choice of Feeders Is Important When First Establishing iPSCs Derived From Primarily Cultured Human Deciduous Tooth Dental Pulp Cells 9
Issei Saitoh, Emi Inada, Yoko Iwase, Hirofumi Noguchi, Tomoya Murakami, Miki Soda, Naoko Kubota, Hiroko Hasegawa, Eri Akasaka, Yuko Matsumoto, Kyoko Oka, Youichi Yamasaki, Haruaki Hayasaki, Masahiro Sato

Review
Islet Culture/Preservation Before Islet Transplantation 25
Hirofumi Noguchi, Chika Miyagi-Shiohira, Kiyoto KurimaNaoya Kobayashi, Issei Saitoh, Masami Watanabe, Yasufumi Noguchi, and Masayuki Matsushita

Efficient Gene Transduction of Dispersed Islet Cells in Culture Using Fiber-Modified Adenoviral Vectors 31
Hiroyuki Hanayama, Kazuo OhashiRie Utoh, Hirofumi Shimizu, Kazuya IseFuminori Sakurai, Hiroyuki Mizuguchi, Hiroyuki Tsuchiya, Teruo Okano, and Mitsukazu Gotoh

Human Laminin Isotype Coating for Creating Islet Cell Sheets 39
Shingo Yamashita, Kazuo OhashiRie UtohTeruo Okano, and Masakazu Yamamoto

Spheroid Formation and Evaluation of Hepatic Cells in a Three-Dimensional Culture Device 47
Yoshitaka Miyamoto, Masashi Ikeuchi, Hirofumi Noguchi, Tohru Yagi, and Shuji Hayashi

Fluorescence Quenching of CdSe/ZnS Quantum Dots by Using Black Hole Quencher Molecules Intermediated With Peptide for Biosensing Application 57
Sreenadh Sasidharan Pillai, Hiroshi Yukawa, Daisuke OnoshimaVasudevanpillai Biju, and Yoshinobu Baba

Volume 7, Number 3

Immature Dental Pulp Stem Cells Showed Renotropic and Pericyte-Like Properties in Acute Renal Failure in Rats 95
Michele A. Barros, Joao Flavio Panattoni Martins, Durvanei Augusto Maria, Crisitiane Valverde Wenceslau, Dener Madeiro De Souza, Alexandre Kerkis, Niels Olsen S. Camara, Julio Cesar C. Balieiro, and Irina Kerkis

A Rotating Bioreactor for Scalable Culture and Differentiation of Respiratory Epithelium 109

Micha Sam Brickman Raredon, Mahboobe Ghaedi, Elizabeth A. Calle, and Laura E. Niklason

A Combination of Low-Intensity Pulsed Ultrasound and Nanohydroxyapatite Concordantly Enhances Osteogenesis of Adipose-Derived Stem Cells From Buccal Fat Pad 123
Rika Nagasaki, Yoshiki Mukudai, Yasumasa Yoshizawa, Masahiro Nagasaki, Sunao Shiogama, Maiko Suzuki, Seiji Kondo, Satoru Shintani, and Tatsuo Shirota

Review

Disease and Stem Cell-Based Analysis of the 2014 ASNTR Meeting 133
David J. Eve

Volume 7, Number 2

JSOPMB Issue

Basic and Clinical Science for Organ Biology

Hirofumi Noguchi, Guest Editor-in-Chief, JSOPMB Issue

Synergistic Effects of Calcineurin Inhibitors and Steroids on Steroid Sensitivity of Peripheral Blood Mononuclear Cells            
Hironori Takeuchi, Hitoshi Iwamoto, Yuki Nakamura, Toshihiko Hirano, Osamu Konno, Yu Kihara, Naokazu Chiba, Takayoshi Yokoyama, Kiminori Takano, Tatsunori Toraishi, Kiyoshi Okuyama, Chie Ikeda, Sachiko Tanaka, Kenji Onda, Akiko Soga, Yukiko Kikuchi, Takashi Kawaguchi, Shigeyuki Kawachi, Sakae Unezaki, and Motohide Shimazu

Improvement of Infusion Process in Cell Transplantation: Effect of Shear Stress on Hepatocyte Viability Under Horizontal and Vertical Syringe Orientation

Sandi Sufiandi, Hiromichi Obara, Shin Enosawa, Huai-Che Hsu, Naoto Matsuno, and Hiroshi Mizunuma

Three-Dimensional In Vitro Hepatic Constructs Formed Using Combinatorial Tapered Stencil for Cluster Culture (TASCL) Device

Yoshitaka Miyamoto, Masashi Ikeuchi, Hirofumi Noguchi, TohruYagi, and Shuji Hayashi

Influence of Autofluorescence Derived From Living Body on In Vivo Fluorescence Imaging Using Quantum Dots

Hiroshi Yukawa, Masaki Watanabe, Noritada Kaji, and Yoshinobu Baba

Potential Factors for the Differentiation of ESCs/iPSCs Into Insulin-Producing Cells

Takako Tsugata, Naruo Nikoh, Tatsuya Kin, Issei Saitoh, Yasufumi Noguchi, Hideo Ueki, Masami Watanabe, Andrew M. James Shapiro, and Hirofumi Noguchi

Volume 7, Number 1

Review

Application of Induced Pluripotent Stem Cells in Liver Diseases 1
Yue Yu, Xuehao Wang, and Scott L. Nyberg

Original Contribution

Integration-Free Human Induced Pluripotent Stem Cells From Type 1 Diabetes Patient Skin Fibroblasts Show Increased Abundance of Pancreas-Specific microRNAs 15
Jun Liu, Mugdha V. Joglekar, Huseyin Sumer, Anandwardhan A. Hardikar, Halena Teede, and Paul J. Verma

Human Menstrual Blood-Derived Mesenchymal Cells as New Human Feeder Layer System for Human Embryonic Stem Cells 25
Danubia Silva dos Santos, Vanessa Carvalho Coelho de Oliveira, Karina Dutra Asensi, Leandro Vairo, Adriana Bastos Carvalho, Antonio Carlos Campos de Carvalho, and Regina Coeli dos Santos Goldenberg

Preculturing Islets With Adipose-Derived Mesenchymal Stromal Cells Is an Effective Strategy for Improving Transplantation Efficiency at the Clinically Preferred Intraportal Site
Chloe L. Rackham, Paramjeet K. Dhadda, Aurelie M. Le Lay, Aileen J. F. King, and Peter M. Jones

Volume 6, Number 3

Original Contribution

Autologous Skeletal Myoblast Sheet Therapy for Porcine Myocardial Infarction Without Increasing Risk of Arrhythmia
Yutaka Terajima, Tatsuya Shimizu, Shinpei Tsuruyama, Hidekazu Sekine, Hikaru Ishii, Kenji Yamazaki, Nobuhisa Hagiwara, and Teruo Okano

Reviews

Estrogen Replacement Therapy for Stroke
Mibel Pabon, Cyrus Tamboli, Sarosh Tamboli, Sandra Acosta, Ike De La Pena, Paul R. Sanberg, Naoki Tajiri, Yuji Kaneko, and Cesar V. Borlongan

Oligodendrocytes Engineered With Migratory Proteins as Effective Graft Source for Cell Transplantation in Multiple Sclerosis
Ike De La Pena, Mibel Pabon, Sandra Acosta, Paul R. Sanberg, Naoki Tajiri, Yuji Kaneko, and Cesar V. Borlongan

Disease and Stem Cell-Based Analysis of the 2013 ASNTR Meeting
David J. Eve

Volume 6, Numbers 1–2

Organ Biology—New Development
Hirofumi Noguchi, Guest Editor in Chief, JSOPMB Issue

Comparison of New Preservation Solutions, HN-1 and University of Wisconsin Solution, in Pancreas Preservation for Porcine Islet Isolation
Akihiro Katayama, Hirofumi Noguchi, Takashi Kuise, Atsuko Nakatsuka, Daisho Hirota, Hitomi Usui Kataoka, Takashi Kawai, Kentaro Inoue, Noriko Imagawa, Issei Saitoh, Yasufumi Noguchi, Masami Watanabe, Jun Wada, and Toshiyoshi Fujiwara

Comparison of Incubation Solutions Prior to the Purification of Porcine Islet Cells
Takashi Kawai, Hirofumi Noguchi, Takashi Kuise, Atsuko Nakatsuka, Akihiro Katayama, Noriko Imagawa, Hitomi Usui Kataoka, Issei Saitoh, Yasufumi Noguchi, Masami Watanabe, and Toshiyoshi Fujiwara

Maintenance of Viability and Function of Rat Islets With the Use of ROCK Inhibitor Y-27632
Yasuhiro Kubota, Hirofumi Noguchi, Masayuki Seita, Takeshi Yuasa, Hiromi Sasamoto, Shuhei Nakaji, Teru Okitsu, Toshiyoshi Fujiwara, and Naoya Kobayashi

Development of Canine Models of Type 1 Diabetes With Partial Pancreatectomy and the Administration of Streptozotocin
Masayuki Seita, Hirofumi Noguchi, Yasuhiro Kubota, Hironobu Kawamoto, Shuhei Nakaji, Naoya Kobayashi, and Toshiyoshi Fujiwara

Quality of Air-Transported Human Islets for Single Islet Cell Preparations
Shingo Yamashita, Kazuo Ohashi, Rie Utoh, Tatsuya Kin, A. M. James Shapiro, Masakazu Yamamoto, Mitsukazu Gotoh, and Teruo Okano

Comparison of the Pharmacological Efficacies of Immunosuppressive Drugs Evaluated by the ATP Production and Mitochondrial Activity in Human Lymphocytes
Hiroyasu Sasahara, Kentaro Sugiyama, Mahoto Tsukaguchi, Kazuya Isogai, Akira Toyama, Hiroshi Satoh, Kazuhide Saitoh, Yuki Nakagawa, Kota Takahashi, Sachiko Tanaka, Kenji Onda, and Toshihiko Hirano

Peripheral Lymphocyte Response to Mycophenolic Acid In Vitro and Incidence of Cytomegalovirus Infection in Renal Transplantation
Kentaro Sugiyama, Hiroyasu Sasahara, Mahoto Tsukaguchi, Kazuya Isogai, Akira Toyama, Hiroshi Satoh, Kazuhide Saitoh, Yuki Nakagawa, Kota Takahashi, Sachiko Tanaka, Kenji Onda, and Toshihiko Hirano

Experimental Nonalcoholic Steatohepatitis Induced by Neonatal Streptozotocin Injection and a High-Fat Diet in Rats
Huai-Che Hsu, Masaharu Dozen, Naoto Matsuno, Hiromichi Obara, Ryou Tanaka, and Shin Enosawa

Electron Therapy Attenuated Elevated Alanine Aminotransferase and Oxidative Stress Values in Type 2 Diabetes-Induced Nonalcoholic Steatohepatitis of Rats
Shin Enosawa, Masaharu Dozen, Yuki Tada, and Keisuke Hirasawa

STO Feeder Cells Are Useful for Propagation of Primarily Cultured Human Deciduous Dental Pulp Cells by Eliminating Contaminating Bacteria and Promoting Cellular Outgrowth
Tomoya Murakami, Issei Saitoh, Emi Inada, Mie Kurosawa, Yoko Iwase, Hirofumi Noguchi, Yutaka Terao, Youichi Yamasaki, Haruaki Hayasaki, and Masahiro Sato

Induced Pluripotent Stem Cell Labeling Using Quantum Dots
Hiroshi Yukawa, Kaoru Suzuki, Yuki Kano, Tatsuya Yamada, Noritada Kaji, Tetsuya Ishikawa, and Yoshinobu Baba

Adipose Tissue-Derived Stem Cell Imaging Using Cadmium-Free Quantum Dots
Yoshiyuki Miyazaki, Hiroshi Yukawa, Hiroyasu Nishi, Yukihiro Okamoto, Noritada Kaji, Tsukasa Torimoto, and Yoshinobu Baba

Volume 5, Numbers 2-3

Japan Society for Organ Preservation and Medical Biology (JSOPMB)

Long-Expected New Start
Hirofumi Noguchi, Guest Editor-in-Chief, JSOPMB Issue

Reviews

Bioimaging of Transgenic Rats Established at Jichi Medical University: Applications in Transplantation Research
Takumi Teratani and Eiji Kobayashi

ER Stress and b-Cell Pathogenesis of Type 1 and Type 2 Diabetes and Islet Transplantation
Hitomi Usui Kataoka and Hirofumi Noguchi

A Review of Autologous Islet Transplantation
Michihiro Maruyama, Takashi Kenmochi, Naotake Akutsu, Kazunori Otsuki, Taihei Ito, Ikuko Matsumoto, and Takehide Asano

Original Contributions

Culture Conditions for Mouse Pancreatic Stem Cells
Hirofumi Noguchi, Issei Saitoh, Hitomi Usui Kataoka, Masami Watanabe, Yasufumi Noguchi, and Toshiyoshi Fujiwara

Isolation Efficiency of Mouse Pancreatic Stem Cells Is Age Dependent
Takashi Kuise, Hirofumi Noguchi, Issei Saitoh, Hitomi Usui Kataoka, Masami Watanabe, Yasufumi Noguchi, and Toshiyoshi Fujiwara

Use of Mesenchymal Stem Cell-Conditioned Medium to Activate Islets in Preservation Solution
Naoya Kasahara, Takumi Teratani, Junshi Doi, Yuki Iijima, Masashi Maeda, Shinji Uemoto, Yasuhiro Fujimoto, Naohiro Sata, Yoshikazu Yasuda, and Eiji Kobayashi

Inhibition of Hepatic Ischemic Reperfusion Injury Using Saline Exposed to Electron Discharge in a Rat Model
Masaharu Dozen, Shin Enosawa, Yuki Tada, and Keisuke Hirasawa

Observation of Positively Charged Magnetic Nanoparticles Inside HepG2 Spheroids Using Electron Microscopy
Yoshitaka Miyamoto, Yumie Koshidaka, Hirofumi Noguchi, Koichi Oishi, Hiroaki Saito, Hiroshi Yukawa, Noritada Kaji, Takeshi Ikeya, Satoshi Suzuki, Hisashi Iwata, Yoshinobu Baba, Katsutoshi Murase, and Shuji Hayashi

Improved Recovery of Hepatocytes Isolated From Warm Ischemic Rat Liver by Citrate Phosphate Dextrose (CPD)-Supplemented Euro-Collins Solution
Huai-Che Hsu, Naoto Matsuno, Noboru Machida, and Shin Enosawa

Volume 5, Number 1

Review

Human Liver Progenitor Cells for Liver Repair
Catherine A. Lombard, Julie Prigent, and Etienne M. Sokal

Original Contributions

Transplantation of Human Adipose Tissue-Derived Mesenchymal Stem Cells Restores the Neurobehavioral Disorders of Rats With Neonatal Hypoxic-Ischemic Encephalopathy
Dongsun Park, Sun Hee Lee, Dae Kwon Bae, Yun-Hui Yang, Goeun Yang, Jangbeen Kyung, Dajeong Kim, Ehn-Kyoung Choi, Jin Tae Hong, Il Seob Shin, Sung Keun Kang, Jeong Chan Ra, and Yun-Bae Kim

Phenotype and Stability of Neural Differentiation of Androgenetic Murine ES Cell-Derived Neural Progenitor Cells
Wanja Wolber, Ruhel Ahmad, Soon Won Choi, Sigrid Eckardt, K. John McLaughlin, Jessica Schmitt, Christian Geis, Manfred Heckmann, Anna-Leena Siren, and Albrecht M. Muller

Volume 4, Number 3

Simple Machine Perfusion Significantly Enhances Hepatocyte Yields of Ischemic and Fresh Rat Livers
Maria-Louisa Izamis, Candice Calhoun, Basak E. Uygun, Maria Angela Guzzardi, Gavrielle Price, Martha Luitje, Nima Saeidi, Martin L. Yarmush, and Korkut Uygun

Human Decidua-Derived Mesenchymal Cells Are a Promising Source for the Generation and Cell Banking of Human Induced Pluripotent Stem Cells
Tomoko Shofuda, Daisuke Kanematsu, Hayato Fukusumi, Atsuyo Yamamoto, Yohei Bamba, Sumiko Yoshitatsu, Hiroshi Suemizu, Masato Nakamura, Yoshikazu Sugimoto, Miho Kusuda Furue, Arihiro Kohara, Wado Akamatsu, Yohei Okada, Hideyuki Okano, Mami Yamasaki, and Yonehiro Kanemura

Brief Communication

Cell Persistence of Allogeneic Keratinocytes and Fibroblasts Applied in a Fibrin Matrix to Acute, Full Thickness Wounds
Jaime E. Dickerson Jr., John V. Planz, Barry T. Reece, Kathy A. Weedon, Sandy D. Kirkpatrick, and Herbert B. Slade

Volume 4, Number 2

Nestin Overexpression Precedes Caspase-3 Upregulation in Rats Exposed to Controlled Cortical Impact Traumatic Brain Injury
Yuji Kaneko, Naoki Tajiri, SeongJin Yu, Takuro Hayashi, Christine E. Stahl, Eunkyung Bae, Humberto Mestre, Nicholas Franzese, Antonio Rodrigues Jr., Maria C. Rodrigues, Hiroto Ishikawa, Kazutaka Shinozuka, Whitney Hethorn, Nathan Weinbren, Loren E. Glover, Jun Tan, Anilkumar Harapanahalli Achyuta, Harry van Loveren, Paul R. Sanberg, Sundaram Shivsankar, and Cesar V. Borlongan

The Effect of CXCR4 Overexpression on Mesenchymal Stem Cell Transplantation in Ischemic Stroke
Oh Young Bang, Kyung Sil Jin, Mi Na Hwang, Ho Young Kang, Byoung Joon Kim, Sang Jin Lee, Sangmee Kang, Yu Kyeong Hwang, Jong Seong Ahn, and Ki Woong Sung

Use of Magnetocapsules for In Vivo Visualization and Enhanced Survival of Xenogeneic HepG2 Cell Transplants
Thomas W. Link, Dian R. Arifin, Christopher M. Long, Piotr Walczak, Naser Muja, Aravind Arepally, and Jeff W. M. Bulte

Improved Hepatocyte Engraftment After Portal Vein Occlusion in LDL Receptor-Deficient WHHL Rabbits and Lentiviral-Mediated Phenotypic Correction In Vitro
Sylvie Goulinet-Mainot, Hadrien Tranchart, Marie-Thérèse Groyer-Picard, Panagiotis Lainas, Papa Saloum Diop, Delphine Holopherne, Patrick Gonin, Karim Benihoud, Nathalie Ba, Olivier Gauthier, Dominique Franco, Catherine Guettier, Danièle Pariente, Anne Weber, Ibrahim Dagher, and Tuan Huy Nguyen

Behavior of Human Articular Chondrocytes During In Vivo Culture in Closed, Permeable Chambers
Iñigo Martinez-Zubiaurre, Tuija Annala, and Martin Polacek

Volume 4, Number 1

Comparative Analysis of the Immunomodulatory Properties of Equine Adult-Derived Mesenchymal Stem Cells
Danielle D. Carrade, Michael W. Lame, Michael S. Kent, Kaitlin C. Clark, Naomi J. Walker, and Dori L. Borjesson

Comparison of Gingiva, Dental Pulp, and Periodontal Ligament Cells From the Standpoint of Mesenchymal Stem Cell Properties
Koji Otabe, Takeshi Muneta, Nobuyuki Kawashima, Hideaki Suda, Kunikazu Tsuji, and Ichiro Sekiya

Epiphyseal Chondroprogenitors Provide a Stable Cell Source for Cartilage Cell Therapy
Salim Darwiche, Corinne Scaletta, Wassim Raffoul, Dominique P. Pioletti, and Lee Ann Applegate

Bioartificial Renal Epithelial Cell System (BRECS): A Compact, Cryopreservable Extracorporeal Renal Replacement Device
Deborah A. Buffington, Christopher J. Pino, Lijun Chen, Angela J. Westover, Gretchen Hageman, and H. David Humes

Adequate Time Window and Environmental Factors Supporting Retinal Graft Cell Survival in rd Mice
Michiko Mandai, Kohei Homma, Satoshi Okamoto, Chikako Yamada, Akane Nomori, and Masayo Takahashi

VOLUME 3, NUMBERS 1-3

Organ/Cell Transplantation and Regenerative Medicine
Hirofumi Noguchi, Guest Editor-in-Chief, JSOPMB Issue

In Vivo Bioimaging Rats for Translational Research in Cell and Tissue Transplantation
Takumi Teratani and Eiji Kobayashi

Consideration of a Safe Protocol for Hepatocyte Transplantation Using Infantile Pigs
Shin Enosawa, Wenji Yuan, Masaharu Douzen, Atsuko Nakazawa, Takeshi Omasa, Akinari Fukuda, Seisuke Sakamoto, Takanobu Shigeta, and Mureo Kasahara

Construction of Artificial Hepatic Lobule-Like Spheroids on a Three-Dimensional Culture Device
Shin Enosawa, Yoshitaka Miyamoto, Hisayo Kubota, Tomoko Jomura, and Takeshi Ikeya

Hepatocyte Is a Sole Cell Type Responsible for the Production of Coagulation Factor IX In Vivo
Kohei Tatsumi, Kazuo Ohashi, Shigeki Mukobata, Atsushi Kubo, Fumikazu Koyama, Yoshiyuki Nakajima, Midori Shima, and Teruo Okano

A Combined Continuous Density/Osmolality Gradient for Supplemental Purification of Human Islets
Hirofumi Noguchi, Bashoo Naziruddin, Masayuki Shimoda, Daisuke Chujo, Morihito Takita, Koji Sugimoto, Takeshi Itoh, Nicholas Onaca, Marlon F. Levy, and Shinichi Matsumoto

Novel Positive-Charged Nanoparticles for Efficient Magnetic Resonance Imaging of Islet Transplantation
Koichi Oishi, Hirofumi Noguchi, Hiroaki Saito, Hiroshi Yukawa, Yoshitaka Miyamoto, Kenji Ono, Katsutoshi Murase, Makoto Sawada, and Shuji Hayashi

Differentiation of Mouse Pancreatic Stem Cells Into Insulin-Producing Cells by Recombinant Sendai Virus-Mediated Gene Transfer Technology
Hiroshi Yukawa, Hirofumi Noguchi, Koichi Oishi, Yoshitaka Miyamoto, Makoto Inoue, Mamoru Hasegawa, Shuji Hayashi, and Yoshinobu Baba

Eicosapentenoic Acid Attenuates Allograft Rejection in an HLA-B27/EGFP Transgenic Rat Cardiac Transplantation Model
Zhong Liu, Naoyuki Hatayama, Lin Xie, Ken Kato, Ping Zhu, Takahiro Ochiya, Yukitoshi Nagahara, Xiang Hu, and Xiao-Kang Li

Higher Sensitivity of Peripheral Blood Lymphocytes to Endogenous Glucocorticoid in Renal Transplant Recipients Treated With Tacrolimus, as Compared to Those Treated With Cyclosporine
Gulimire Muhetaer, Hironori Takeuchi, Sogo Akizuki, Hitoshi Iwamoto, Motohide Shimazu, Sakae Unezaki, and Toshihiko Hirano

Clinical Significance of the Pharmacological Efficacy of Tacrolimus Estimated by the Lymphocyte Immunosuppressant Sensitivity Test (LIST) Before and After Renal Transplantation
Kentaro Sugiyama, Kazuya Isogai, Akira Toyama, Hiroshi Satoh, Kazuhide Saito, Yuki Nakagawa, Masayuki Tasaki, Kota Takahashi, and Toshihiko Hirano

Cryopreservation of Induced Pluripotent Stem Cells
Yoshitaka Miyamoto, Hirofumi Noguchi, Hiroshi Yukawa, Koichi Oishi, Kenji Matsushita, Hisashi Iwata, and Shuji Hayashi

Generation of Mouse STO Feeder Cell Lines That Confer Resistance to Several Types of Selective Drugs
Issei Saitoh, Masahiro Sato, Yoko Iwase, Emi Inada, Toshiki Nomura, Eri Akasaka, Youichi Yamasaki, and Hirofumi Noguchi

A Simplified In Vitro Teratoma Assay for Pluripotent Stem Cells Injected Into Rodent Fetal Organs
Shigeo Masuda, Takashi Yokoo, Naomi Sugimoto, Masako Doi, Shuh-hei Fujishiro, Kengo Takeuchi, Eiji Kobayashi, and Yutaka Hanazono

Cell Therapy Using Adipose-Derived Stem Cells for Chronic Liver Injury in Mice
Kazuo Ohashi, Yoshinori Matsubara, Kohei Tatsumi, Ayako Kohori, Rie Utoh, Hiroshi Kakidachi, Akihiro Horii, Masahiro Tsutsumi, and Teruo Okano

Isolation of Hepatic Progenitor Cells From Human Liver With Cirrhosis Secondary to Biliary Atresia Using EpCAM or Thy-1 Markers
Taisuke Yamazaki, Shin Enosawa, Mureo Kasahara, Akinari Fukuda, Seisuke Sakamoto, Takanobu Shigeta, Atsuko Nakazawa, and Takayoshi Tokiwa

Side Population Cells From an Immortalized Human Liver Epithelial Cell Line Exhibit Hepatic Stem-Like Cell Properties
Takayoshi Tokiwa, Taisuke Yamazaki, and Shin Enosawa

VOLUME 2, NUMBER 3

Resident Endothelial Progenitor Cells From Human Placenta Have Greater Vasculogenic Potential Than Circulating Endothelial Progenitor Cells From Umbilical Cord Blood
Brian M. Rapp, M. Reza Saadatzedeh, Richard H. Ofstein, Janak R. Bhavsar, Zachary S. Tempel, Oscar Moreno, Peter Morone, Dana A. Booth, Dmitry O. Traktuev, Michael C. Dalsing, David A. Ingram, Mervin C. Yoder, Keith L. March, and Michael P. Murphy

Validation of Islet Transport From a Geographically Distant Isolation Center Enabling Equitable Access and National Health Service Funding of a Clinical Islet Transplant Program for England
Ali Aldibbiat, Guo Cai Huang, Min Zhao, Graham N. Holliman, Linda Ferguson, Stephen Hughes, Ken Brigham, Julie Wardle, Rob Williams, Anne Dickinson, Steven A. White, Paul R. V. Johnson, Derek Manas, Stephanie A. Amiel, and James A. M. Shaw

Brief Communication

Hypothermic Perfusion Preservation of Pancreas for Islet Grafts: Validation Using a Split Lobe Porcine Model
B. P. Weegman, M. J. Taylor, S. C. Baicu, W. E. Scott, III, K. R. Mueller, J. D. Kitzmann, M. D. Rizzari, and K. K. Papas

VOLUME 2, NUMBER 2

Review

Mesenchymal Stromal Cells as a Therapeutic Strategy to Support Islet Transplantation in Type 1 Diabetes Mellitus
Sarah A. Busch, Saskia T. J. van Crutchen, Robert J. Deans, and Anthony E. Ting

Original Contributions

Early Immunomodulation by Intravenously Transplanted Mesenchymal Stem Cells Promotes Functional Recovery in Spinal Cord Injured Rats
Jung Hwa Seo, In Keun Jang, Hyongbum Kim, Mal Sook Yang, Jong Eun Lee, Hyo Eun Kim, Yong-Woo Eom, Doo-Hoon Lee, Ji Hea Yu, Ji Yeon Kim, Hyun Ok Kim, and Sung-Rae Cho

Neuroprotective and Angiogenic Effects of Bone Marrow Transplantation Combined With Granulocyte Colony-Stimulating Factor in a Mouse Model of Amyotrophic Lateral Sclerosis
Yasuyuki Ohta, Makiko Nagai, Kazunori Miyazaki, Nobuhito Tanaka, Hiromi Kawai, Takafumi Mimoto, Nobutoshi Morimoto, Tomoko Kurata, Yoshio Ikeda, Tohru Matsuura, and Koji Abe

Volume 2, Supplement 1

Cell Transplant Track Abstracts from the Cell Transplant Society - International Xenotransplantation Association 2011 Joint International Congress

Author Index for Cell Transplant Track Abstracts from the Cell Transplant Society - International Xenotransplantation Association 2011 Joint International Congress

Volume 2, Number 1

Reviews

Prospects for Induced Pluripotent Stem Cell-Derived Hepatocytes in Cell Therapy
Masaya Iwamuro, Javed M. Shahid, Kazuhide Yamamoto, and Naoya Kobayashi

Management of Liver Failure: From Transplantation to Cell-Based Therapy
Maria Giovanna Francipane, Melchiorre Cervello, Giovanni Battista Vizzini, Giada Pietrosi, and Giuseppe Montalto

Original Contribution

Upregulation of Adipogenesis and Chondrogenesis in MSC Serum-Free Culture
Saey Tuan Barnabas Ho, Vivek Madhukar Tanavde, James Hoi Hui, and Eng Hin Lee

Volume 1, Number 3

Commentary

Tracking Cells Without Leaving a Trace
Stephen Strom

Original Contributions

Autografting of Renal Progenitor Cells Ameliorates Kidney Damage in Experimental Model of Pyelonephritis
Abdol-Mohammad Kajbafzadeh, Azadeh Elmi, Saman Shafaat Talab, Zhina Sadeghi, Hamed Emami, and Masoud Sotoudeh

Monitoring of Liver Cell Transplantation in a Preclinical Swine Model Using Magnetic Resonance Imaging
Nathanael Raschzok, Ulf Teichgräber, Nils Billecke, Anja Zielinski, Kirsten Steinz, Nora N. Kammer, Mehmet H. Morgul, Sarah Schmeisser, Michaela K. Adonopoulou, Lars Morawietz, Bernhard Hiebl, Ruth Schwartlander, Wolfgang Rüdinger, Bernd Hamm, Peter Neuhaus, and Igor M. Sauer

Acute Treatment With Herbal Extracts Provides Neuroprotective Benefits in In Vitro and In Vivo Stroke Models, Characterized by Reduced Ischemic Cell Death and Maintenance of Motor and Neurological Functions
Yuji Kaneko, David J. Eve, SeongJin Yu, Hideki Shojo, Eunkyung Cate Bae, Dong-Hyuk Park, Bill Roschek, Jr., Randall S. Alberte, Paul R. Sanberg, Cyndy D. Sanberg, Paula C. Bickford, and Cesar V. Borlongan


Volume 1, Number 2

Original Contributions

Intracerebroventricular Transplantation of Cord Blood-Derived Neural Progenitors in a Child With Severe Global Brain Ischemic Injury
Sergiusz Jozwiak, Aleksandra Habich, Katarzyna Kotulska, Anna Sarnowska, Tomasz Kropiwnicki, Miroslaw Janowski, Elzbieta Jurkiewicz, Barbara Lukomska, Tomasz Kmiec, Jerzy Walecki, Marcin Roszkowski, Mieczyslaw Litwin, Tomasz Oldak, Dariusz Boruczkowski, and Krystyna Domanska-Janik

Transplant of Primary Human Hepatocytes Cocultured With Bone Marrow Stromal Cells to SCID Alb-uPA Mice
S. A. Mohajerani, M. Nourbakhsh, A. Cadili, J. R. Lakey, and N. M. Kneteman

In Vivo Growing of New Cell Colonies in a Portion of Bone Marrow: Potential Use for Indirect Cell Therapy
Ana Manzanedo, Fidel Rodriguez, Jose A. Obeso, and Manuel Rodriguez

Effects of Quantum Dot Labeling on Endothelial Progenitor Cell Function and Viability
Matyas Molnar, Peter Friberg, Ying Fu, Mikeal Brisslert, Michael Adams, and Yun Chen

Volume 1, Number 1

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Cell Medicine

Brazilian researchers find human menstrual blood-derived cells “feed” embryonic stem cells
Technique preserves the undifferentiated nature of hESCs destined for transplantation

Tampa, Fla. (May 28, 2014)—To be suitable for medical transplantation, one idea is that human embryonic stem cells (hESCs) need to remain “undifferentiated” i.e. they are not changing into other cell types. In determining the best way to culture hESCs so that they remain undifferentiated and also grow, proliferate and survive, researchers have used blood cell “feeder-layer” cultures using animal-derived feeder cells, often from mice [mouse embryonic fibroblasts (MEFs)]. This approach has, however, been associated with a variety of contamination problems, including pathogen and viral transmission.

To avoid contamination problems, a Brazilian research team has investigated the use of human menstrual blood-derived mesenchymal cells (MBMCs) as feeder layers and found that “MBMCs can replace animal-derived feeder systems in human embryonic stem cell culture systems and support their growth in an undifferentiated stage.”

The study will be published in a future issue of Cell Medicine, but is currently freely available on-line as an unedited early e-pub at: http://www.ingentaconnect.com/content/cog/cm/pre-prints/content-CM1019silvadosSantos

“Human embryonic stem cells present a continuous proliferation in an undifferentiated state, resulting in an unlimited amount of cells with the potential to differentiate toward any type of cell in the human body,” said study corresponding author Dr. Regina Coeli dos Santos Goldenberg of the Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro. “These characteristics make hESCs good candidates for cell based therapies.”

Feeder-layers for hESCs comprised of MEFs have been efficiently used for decades but, because of the clinical drawbacks, the authors subsequently experimented with human menstrual blood cells as a potential replacement for animal-derived feeder-layers, not only for negating the contamination issues, but also because human menstrual blood is so accessible. MBMCs are without ethical encumbrances and shortages, nor are they difficult to access—a problem with other human cells, such as umbilical cord blood cells, adult bone marrow cells or placenta cells.

“Menstrual blood is derived from uterine tissues,” explained the researchers. “These cells are widely available 12 times a year from women of child-bearing age. The cells are easily obtained, possess the capability of long-term proliferation and are clinically compatible with hESCs-derived cells.”

The researchers found that their culture system using MBMCs as a feeder-layer for hESCs are the “closest and more suitable alternative to animal-free conditions for growing hESCs” and a “good candidate for large-expansion of cells for clinical application.” They also found no difference in growth factor expression when comparing the use of growth factors in both the standard feeder system using animal cells and the feeder system they tested using hESCs.

“It is also noteworthy to highlight that our group reported the rapid and efficient generation of induced pluripotent stem cells (iPSCs) from MBMCs, indicating that these cells can be used as a model to study patient-specific disease and that in the future they might be used in clinical settings.”

“This study provides a new means of culturing hESCs without potential xenocontamination and after further study to confirm that there is no contamination of the ESCs with the feeder cells, this could prove to be a viable way to culture ESCs for clinical purposes” said Dr. Maria C. O. Rodrigues, at the Ribeirão Preto School of Medicine, University of Sao Paulo, Brazil and section editor for Cell Medicine.

Citation: Silva dos Santos, D.; Coelho de Oliveira, V. C.; Asensi, K. D.; Vairo, L.; Carvalho, A. B.; Campos de Carvalho, A. C.; Goldenberg, R. C. dos S. Human Menstrual Blood Derived Mesenchymal Cells As New Human Feederlayer System For Human Embryonic Stem Cells. Cell Med. Appeared or available online March 3, 2014.

Contact: Dr. Regina Coeli dos Santos Goldenberg, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Av Carlos Chagas Filho 373 Bloco G-Sala G2-053, Rio de Janeiro, RJ 21941-902, Brazil. Tel: +55 21 2562 6559 Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

The editorial offices for CELL MEDICINE are at the Center of Excellence for Aging and Brain Repair, College of Medicine, the University of South Florida. Contact: David Eve, Ph.D. at This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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